Making important raw materials for fine chemicals out of carbon dioxide really works. As part of the Max Planck collaborative project eBioCO2n, a team of researchers from Fraunhofer IGB have successfully performed a first ever fixation of CO2 via a multi-enzyme enzyme reaction driven by electricity yielding a prospective intermediate for the chemical industry. The process for electro-biocatalytic CO2 fixation was recently published and is…

Protection against game damage - 13/01/2022

Sapling protectors made of domestic wood - simple but effective

Young forest plants need protecting against damage and as a result it’s often hard to miss the colourful plastic tree guard sleeves when out walking in forests. These tree guard sleeves are neither pleasing to the eye nor sustainable. Bernd Schairer UG from Albstadt has developed sapling protectors made of wood that contain no plastics, metals or chemicals, do not require removal and disposal, and are produced in a socially responsible way.

Chitin is the main component of insect carapaces and ensures that they are both stable and flexible. The Chitinfluid research project, funded by the Carl Zeiss Foundation, focuses on the use of chitin in construction and aims to process chitin and its derivatives into sustainable materials. In a hybrid symposium under the auspices of Prof. Sabine Laschat from the University of Stuttgart, the project team discussed the current state of research…

The incidence of colorectal cancers in young adults is increasing. At the same time, the proportion of overweight and obese young people is also on the rise. Whether there is a connection between these two observations, however, was not known until now. Scientists at the DKFZ have now shown that the risk of early colorectal cancer is significantly increased in overweight young people compared to normal-weight peers.

Genetic alterations that promote the development and spread of tumors are difficult to identify. This is especially true for mutations in the non-protein-coding regions of the genome, which include all important regulatory sequences. Scientists at the German Cancer Research Center have now published an algorithm that detects cancer drivers in both the protein-coding and non-coding regions of the genome.

The cochlear implant (CI) is the most successful neural prosthesis worldwide. Thanks to direct stimulation of the auditory nerve, it enables more than half a million people worldwide to hear, even though those affected were born deaf or deafened.

Researchers at Heidelberg University Hospital (UKHD), the German Cancer Research Center (DKFZ) and at the National Center for Tumor Diseases (NCT) Heidelberg have demonstrated for the first time that there is a link between the development of colorectal cancer in individuals with Lynch syndrome and the composition of immune cells in the colorectal mucosa.

The International Agency for Research on Cancer (IARC), an agency of the World Health Organization (WHO), will soon publish the first edition of its classification of childhood cancers. The new WHO classification forms the basis of modern, precise cancer diagnostics for physicians and pediatric oncologists worldwide and is based on the latest international research findings.

Dossier - 16/12/2021

Advanced therapy medicinal products: gene and cell therapies

Novel gene and cell therapies for treating incurable and hereditary diseases have raised high expectations. However, success has so far been limited to the long-established bone marrow transplants involving the administration of haematopoietic stem cells used to treat blood cancer. CAR T-cell therapies have recently emerged as a major new hope in cancer treatment.

For the second time, the nova Institute for Ecology and Innovation is honouring outstanding scientific research that provides sustainable solutions for the cellulose fibre value chain as part of the "International Conference on Cellulose Fibres 2022". The DITF Denkendorf is one of the six nominees.

Plant residues - 14/12/2021

Straw pulp: agricultural residues become sanitary paper products

Straw cannot yet be spun into gold, but in Mannheim, Germany, it is being turned into something else of great value: Essity is the first and only company in Europe to produce toilet paper and kitchen rolls from wheat straw in a new pulp mill. From next year, these sustainable sanitary paper products will be found on supermarket shelves.

Today, the EU Parliament adopted the EU Regulation on Health Technology Assessment (HTA), which includes not only new medicines (including gene and cell therapies), but also medical devices.

A new interdisciplinary research project aims to uncover information that can help decode hereditary colon cancer with the aid of mathematical models. Mathematicians and tumour biologists of Heidelberg University, the Heidelberg Institute for Theoretical Studies, Heidelberg University Hospital, and the German Cancer Research Center are collaborating on the project.

Renewable raw materials and the circular economy in the textile industry - 08/12/2021

Outdoor equipment made from cellulose, castor oil and coffee grounds - functional and durable

VAUDE develops outdoor gear made from natural or recycled materials that are harmless to people and the environment while protecting against the wind and rain. The company relies on renewable raw materials, biobased plastics and the circular economy.

The development of immunotherapies against blood cancer could be more successful if T cells are activated moderately rather than excessively. Scientists from the German Cancer Research Center have now been able to show this in mice: If the researchers blocked a cytokine that slows down the immune system, the T cells became exhausted and failed in the fight against leukemia.

At Tübingen University Hospital, a preclinical study led by Dr. Clemens Hinterleitner and Prof. Dr. Lars Zender, Medical Director of Medical Oncology and Pneumology, led to extremely promising results. The research group was able to develop a new methodology that makes it possible to better predict the likelihood of success of immunotherapies for lung cancer.

Press release - 03/12/2021

ARDIA-Net preliminary results presented in the Kick-Off Conference of Interreg Alpine Space 2021-27

The Kick-Off Conference of the new Interreg Alpine Space programme, which gathered more than 300 attendees, was organized by the Joint Secretariat in Salzburg and held online due to the COVID-19 restrictions established by the Austrian Government days previous to the celebration. It consisted of a two half-day programme (22nd and 23rd of November) under the motto “Let’s change our altitude”.

Gene regulation as a starting point for cancer therapies - 02/12/2021

New investigation method for deciphering complex epigenetic networks

The development and maintenance of uncontrolled cell division in tumours is often due to the unbalanced, complex interplay of regulatory epigenetic networks. Researchers at the Institute of Biochemistry and Technical Biochemistry in Stuttgart have developed a new screening system to identify essential components that can serve as targets for anticancer drugs.

Parkinson's disease is characterised by a slow, progressive loss of nerve cells in certain brain areas. The disease is still incurable and the exact causes are unclear. The dopamine deficiency in the brain can only be controlled to some extent in the initial phase of the disease. Basic research is being conducted in an attempt to unravel the mystery of Parkinson's disease.

In multiple myeloma, a cancer of the bone marrow, relapse almost always occurs after treatment. Initially, most patients respond well to therapy. However, as the disease progresses, resistant cancer cells spread in the bone marrow, with fatal consequences for the patients.

Laboratory automation - 29/11/2021

Reaching the goal quickly and efficiently with the help of artificial intelligence

Medical research is slow, costly and time-consuming. The system developed by the start-up LABMaiTE could soon change that. With the help of artificial intelligence, it will be possible to automate laboratory experiments and collect and analyse data at the same time.

Further utilisation of plant residues - 25/11/2021

Novel fibre composite made from hop fermentation residues

Biogas plants produce energy-rich gas by fermenting biomass. This process generates both liquid and solid fibrous and particulate fermentation residues. Researchers at the German Institutes of Textile and Fibre Research (DITF) have now managed to create a resistant and water-repellent fibre composite material from solid hop residues that can be used as a veneer to coat wood panels.

Cluster of the future - 25/11/2021

nanodiagBW: using nanopores to create completely new diagnostic possibilities

Modern medicine has a wide range of molecular diagnostics at hand. In the next decade, this will increasingly be supplemented by prognostic methods. The BMBF Cluster of the Future finalist, nanodiag BW, is developing prognostic methods to identify epigenetic factors for diseases through a new type of bioanalytics – single molecule analysis in nanopores – which would make it possible to take personalised prevention approaches.

In reforestation projects, the seedlings must be protected. So-called growth covers prevent game from feeding on the young plants and help to ensure that they are not prevented from growing by other plants. Previously used sheaths made of plastic and metal are often not removed in time and pollute the environment. The DITF have developed a biodegradable yarn for growth covers from renewable raw materials.

After a highly competitive process Ulm University has been awarded its fifth Collaborative Research Centre (CRC). The new CRC 1506 ‘Aging at Interfaces’ addresses one of the most urgent medical challenges of our time: the aging of the human body and the diseases and constraints that are frequently associated with the aging process.

At the University Hospital Tübingen, clinical evaluation of an in-house developed vaccine (CoVac-1) against SARS-CoV-2 was started in November 2020 under the direction of Prof. Dr. Juliane Walz in the CCU Translational Immunology of the Medical Clinic (Medical Director Prof. Dr. Helmut Salih). Now the results of the Phase I study are available and demonstrate a potent activation of the T-cell response against the coronavirus.

The Cluster of Excellence IntCDC of the University of Stuttgart presents the "Maison Fibre" at the International Architecture Exhibition Venice. The full-scale inhabitable installation is made from robotically produced, fibrous building elements.

Furtwangen University publishes the world’s first molecular biological study on bacterial contamination of slit lamps. Slit lamps are among the most important tools used by ophthalmologists and opticians. They allow selected areas of the eye to be magnified and examined for diseases.

As cancer progresses, the tumor cells continually change, ultimately resulting in a tumor consisting of a large number of different cell clones with different characteristics. This is referred to as "tumor heterogeneity". In many cases, the cancer cells become resistant to the treatments available.

Treatment resistance is a central problem in the treatment of cancer. Bone and soft tissue tumors – known as sarcomas – in adolescents and young adults often stop responding to treatment too. This is because cancer cells develop a large number of new characteristics as the disease progresses and often become resistant to drugs that were originally effective.

Microfluidic systems - 18/11/2021

Dermagnostix develops molecular diagnostic tests for skin diseases

Dermagnostix GmbH has developed a rapid test to differentiate between psoriasis and eczema. This test is currently undergoing preclinical testing, with market launch planned for 2023. The start-up is already working on two other dermatological tests. Centrifugal microfluidics is the name of the technology on which the tests are based.

Dossier - 17/11/2021

Biorefinery: new paths to build our tomorrow

Sustainability is in vogue. And it’s not a question of wanting to be sustainable, but having to be: as the latest report from the Intergovernmental Panel on Climate Change shows, protecting the climate and the environment calls for swift action. Biorefineries that use renewable raw materials and recycle industrial raw materials are playing an important role in the bioeconomy concepts of many countries - including the state of Baden-Württemberg.

Scientists of the Translational Lung Research Center Heidelberg (TLRC) and the German Cancer Research Center (DKFZ) have discovered a new link between excessive airway mucus and chronic airway inflammation that is characteristic of cystic fibrosis and chronic obstructive pulmonary disease (COPD). The researchers showed that mucus in the airways reprograms certain cells of the immune system.

Doctors and scientists from the German Cancer Research Center (DKFZ) and from Heidelberg University's Medical Faculty Mannheim have successfully tested a neoantigen-specific transgenic immune cell therapy for malignant brain tumors for the first time using an experimental model in mice.

Climate-friendly circular economy - 11/11/2021

CO2 from the air as a raw material for chemicals

A Fraunhofer team has successfully produced a dye using CO2 adsorbed from the air. The aim is to move towards a climate- and resource-friendly circular economy. Chemicals, as well as fuels, can be produced cost-effectively using this process. How does the technical process work, and what opportunities does it open up?

Plastic products can be found everywhere in daily life, soft plastic in particular often being used for packaging or children's toys. These often contain so-called plasticizers which ensure that the material remains flexible. Because plasticizers are not bonded permanently to the plastic, they can escape from the material, meaning they can be absorbed by humans.

rMSI technology - 08/11/2021

New multispectral imaging technology improves endoscopic tumour detection capabilities

The quality of minimally invasive surgery depends to a large extent on the imaging properties of the endoscopes used. The Mannheim-based company Thericon GmbH has developed a multispectral imaging technology that overlays views from multiple light channels in real time to create a detailed image on which tumours can be better identified.

Nanoparticles are omnipresent in our environment: Viruses in ambient air, proteins in the body, as building blocks of new materials for electronics, or in surface coatings. Visualizing these smallest particles is a problem: They are so small that they can hardly be seen under an optical microscope.

Booster for neutrophil granulocytes - 27/10/2021

Acetate supports immune cells to fight against sepsis

Blood poisoning is the most dangerous complication of bacterial infections and often leads to death. Researchers at the Interfaculty Institute of Microbiology and Infection Medicine at the University of Tübingen have now identified acetate as a potent agent for stimulating innate immune system cells, supporting their ability to destroy bacteria.

Rolandic epilepsy is a common form of epilepsy in children which occurs primarily during sleep. Short sounds played during sleep can partially suppress the neuronal discharges characteristic of epilepsy. That’s according to a research team from the University of Tübingen and Tübingen University Hospitals. The team is headed by Dr. Hong-Viet Ngo and Professor Jan Born from the Institute of Medical Psychology and Behavioral Neurobiology.