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31.08.2010

Freiburg BioRegion – a Dynamic Region in the BioValley

Freiburg BioRegion, an attractive and dynamic region offering a high quality of life, is located in Germany but is close to both France and Switzerland. It is a partner of the three-nation BioValley network which combines the biotechnological potential of the centres in Freiburg (D), Basle (CH) and Strasbourg (F).


Mystery of nickel allergies solved

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Researchers from the University of Gießen and the Mannheim Medical Faculty along with colleagues from Freiburg, Münster and Munich, have made a fundamental contribution to deciphering the biological mechanisms behind nickel allergies. The results, which might be of great importance for developing innovative preventive and therapeutic approaches, have now been published in the current edition of “Nature Immunology”.
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Robert Murphy – intelligent computers and insights into cells

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Will humans, who consist of billions of cells and hundreds of billions of molecules, ever understand their own complexity? Robert F. Murphy, External Senior Fellow at the Freiburg Institute for Applied Sciences (FRIAS), is a pioneer in what is known as computational biology. Progress in this discipline is of major importance for medical and pharmaceutical research as well as the agricultural industry.
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Will humans, who consist of billions of cells and hundreds of billions of molecules, ever understand their own complexity? Robert F. Murphy, External Senior Fellow at the Freiburg Institute for Applied Sciences (FRIAS), is a pioneer in what is known as computational biology. This discipline uses mathematical and computational methods to investigate the complexity of biological systems. Progress in this discipline is of major importance for medical and pharmaceutical research as well as the agricultural industry.

Researchers from the University of Gießen and the Mannheim Medical Faculty along with colleagues from Freiburg, Münster and Munich, have made a fundamental contribution to deciphering the biological mechanisms behind nickel allergies. The results, which might be of great importance for developing innovative preventive and therapeutic approaches, have now been published in the current edition of “Nature Immunology”.

The Denzlingen-based company IBAM GbR offers solutions that enable faster and cost-effective drug discovery. IBAM GbR was spun off from the University of Freiburg and supports industrial customers in identifying biochemical targets of potential drugs or the modes of action of enzymes and second messengers in the central nervous system and other tissues. Over the last few years, the company’s managing director Dr. Rainer Knörle, and his partner Dr. Peter Schnierle, have in co-operation with their industrial partners specialised on medicinal plants. The partners use modern biochemical methods to analyse the pharmaceutical effect of traditional medicinal plant extracts such as St. John’s wort, passion fruit, or Greek mountain tea.

The research group led by Prof. Ralf Reski is a moss specialist and has now, for the first time, succeeded in producing a human protein in a moss bioreactor – the complement factor H. The lack of this protein leads to age-related macular degeneration in about 50 million people worldwide. The complement factor H has been assigned ‘orphan drug’ status by the respective EU authorities.

Scientists from the Department of Molecular Immunology at the Faculty of Biology and the Centre for Biological Signalling Studies (BIOSS) at the University of Freiburg have discovered a new mechanism that regulates the development of B-lymphocytes in the human bone marrow.

Helicobacter pylori is a genus of bacteria that inhabits the human stomach. The bacteria can cause duodenal and gastric ulcers and are also linked to the development of gastric cancer. Prof. Dr. Manfred Kist from the Freiburg University Medical Centre has spent around 25 years of his scientific career on investigating H. pylori, a bent, rod-shaped bacterium.

Modern methods used for the production of nitrogen for use in plant fertilisers and other applications are very efficient. Prof. Dr. Oliver Einsle and his team at the University of Freiburg have found a way to investigate the reactive centres of bacterial enzymes. All nitrogen-converting enzymes contain metal ions, and it is these metal ions that mediate the underlying chemical reactions.

From now on, the Bernstein Center Freiburg will become the central facility for coordinating research in the areas of computational neuroscience and neurotechnology in Freiburg. It will combine experimental and theoretical neurosciences and their applications in computer science, microsystems technology, and clinical use into a multidisciplinary research hub.

It’s official: Today, the Science Council approved the University of Freiburg’s proposal for the Freiburg Centre for Interactive Materials and Bioinspired Technologies (FIT). The 23-million-euro project can now get underway. The planned interdisciplinary, interinstitutional and transnational centre will become an innovative research institution with a special focus on basic research into interactive materials and intelligent systems.

Dr. Uwe Schulte of the Freiburg-based biotech company Logopharm GmbH is a specialist in the analysis of membrane proteins, membrane protein complexes and functional networks involving membrane proteins. In an interview with BIOPRO, Schulte expresses his views on the direction research should take.



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Prey animals only become prey when a predator actually discovers and kills them. Dr. Nina Stobbe from the University of Freiburg has spent the last three years investigating the ability of moths to prevent predators from detecting them. Her doctoral thesis has shown that colour spots on the wings of butterflies conceal their bearers, in particular when arranged and structured in a specific way.

Plant research, molecular developmental biology and cell biology, anatomy – these are just a few of the fields in which Prof. Dr. Felicitas Pröls from the University of Freiburg has achieved major success. She has also recently begun looking into molecular neurobiology. “For me, professional diversity is the most important thing and it is also the reason why I am happy with my chosen profession,” said the researcher. And her chosen career path has involved her repeatedly stepping into completely different worlds.

Dr. Michael Richter is the new German BioValley/Freiburg Bioregion coordinator. He succeeds Dr. Thea Siegenführ who has shaped and skilfully organised the biotechnology landscape on the Upper Rhine for the last 16 years.



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