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31.08.2010

Freiburg BioRegion – a Dynamic Region in the BioValley

Freiburg BioRegion, an attractive and dynamic region offering a high quality of life, is located in Germany but is close to both France and Switzerland. It is a partner of the three-nation BioValley network which combines the biotechnological potential of the centres in Freiburg (D), Basle (CH) and Strasbourg (F).


Mystery of nickel allergies solved

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Researchers from the University of Gießen and the Mannheim Medical Faculty along with colleagues from Freiburg, Münster and Munich, have made a fundamental contribution to deciphering the biological mechanisms behind nickel allergies. The results, which might be of great importance for developing innovative preventive and therapeutic approaches, have now been published in the current edition of “Nature Immunology”.
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Robert Murphy – intelligent computers and insights into cells

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Will humans, who consist of billions of cells and hundreds of billions of molecules, ever understand their own complexity? Robert F. Murphy, External Senior Fellow at the Freiburg Institute for Applied Sciences (FRIAS), is a pioneer in what is known as computational biology. Progress in this discipline is of major importance for medical and pharmaceutical research as well as the agricultural industry.
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Robert Murphy – intelligent computers and insights into cells | 29.08.2010 | Science
The photo shows a man with glasses and a poster with FRIAS written on it in the background.<br />
Will humans, who consist of billions of cells and hundreds of billions of molecules, ever understand their own complexity? Robert F. Murphy, External Senior Fellow at the Freiburg Institute for Applied Sciences (FRIAS), is a pioneer in what is known as computational biology. This discipline uses mathematical and computational methods to investigate the complexity of biological systems. Progress in this discipline is of major importance for medical and pharmaceutical research as well as the agricultural industry.

Mystery of nickel allergies solved | 23.08.2010 | Science
Researchers from the University of Gießen and the Mannheim Medical Faculty along with colleagues from Freiburg, Münster and Munich, have made a fundamental contribution to deciphering the biological mechanisms behind nickel allergies. The results, which might be of great importance for developing innovative preventive and therapeutic approaches, have now been published in the current edition of “Nature Immunology”.

IBAM GbR - Enzymes, neurotransmitters and Greek mountain tea | 09.08.2010 | Industry
The photo shows a green building.
The Denzlingen-based company IBAM GbR offers solutions that enable faster and cost-effective drug discovery. IBAM GbR was spun off from the University of Freiburg and supports industrial customers in identifying biochemical targets of potential drugs or the modes of action of enzymes and second messengers in the central nervous system and other tissues. Over the last few years, the company’s managing director Dr. Rainer Knörle, and his partner Dr. Peter Schnierle, have in co-operation with their industrial partners specialised on medicinal plants. The partners use modern biochemical methods to analyse the pharmaceutical effect of traditional medicinal plant extracts such as St. John’s wort, passion fruit, or Greek mountain tea.

Human protein produced in a moss bioreactor | 08.08.2010 | Science
The research group led by Prof. Ralf Reski is a moss specialist and has now, for the first time, succeeded in producing a human protein in a moss bioreactor – the complement factor H. The lack of this protein leads to age-related macular degeneration in about 50 million people worldwide. The complement factor H has been assigned ‘orphan drug’ status by the respective EU authorities.

Light into the darkness of the human immune system | 07.08.2010 | Science
Scientists from the Department of Molecular Immunology at the Faculty of Biology and the Centre for Biological Signalling Studies (BIOSS) at the University of Freiburg have discovered a new mechanism that regulates the development of B-lymphocytes in the human bone marrow.

Manfred Kist – 25 years of fascination for a stomach bacterium | 01.08.2010 | Science
Helicobacter pylori is a genus of bacteria that inhabits the human stomach. The bacteria can cause duodenal and gastric ulcers and are also linked to the development of gastric cancer. Prof. Dr. Manfred Kist from the Freiburg University Medical Centre has spent around 25 years of his scientific career on investigating H. pylori, a bent, rod-shaped bacterium.

Metal cubes, protein landscapes and the global nitrogen cycle | 26.07.2010 | Science
The photo shows coloured spheres surrounded by a dense net of blue lines.<br />
Modern methods used for the production of nitrogen for use in plant fertilisers and other applications are very efficient. Prof. Dr. Oliver Einsle and his team at the University of Freiburg have found a way to investigate the reactive centres of bacterial enzymes. All nitrogen-converting enzymes contain metal ions, and it is these metal ions that mediate the underlying chemical reactions.

Bernstein Center Freiburg | 17.07.2010 | Science
The photo shows the building of the Bernstein Centre Freiburg
From now on, the Bernstein Center Freiburg will become the central facility for coordinating research in the areas of computational neuroscience and neurotechnology in Freiburg. It will combine experimental and theoretical neurosciences and their applications in computer science, microsystems technology, and clinical use into a multidisciplinary research hub.

New Centre for Interactive Materials and Bioinspired Technologies (FIT) | 11.07.2010 | News and Views
The photo shows the Institute of Applied Microsystems Engineering at the University of Freiburg (FMF-Fit)
It’s official: Today, the Science Council approved the University of Freiburg’s proposal for the Freiburg Centre for Interactive Materials and Bioinspired Technologies (FIT). The 23-million-euro project can now get underway. The planned interdisciplinary, interinstitutional and transnational centre will become an innovative research institution with a special focus on basic research into interactive materials and intelligent systems.

Complex issues relating to membranes | 11.07.2010 | Industry
The photo shows the face of a man.
Dr. Uwe Schulte of the Freiburg-based biotech company Logopharm GmbH is a specialist in the analysis of membrane proteins, membrane protein complexes and functional networks involving membrane proteins. In an interview with BIOPRO, Schulte expresses his views on the direction research should take.



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Archive 2009



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Can stem cells treat diabetes? | 11.05.2009 | Science
Stem cells are seen as the miracle cure of the future for many degenerative diseases. Scientists and physicians also hope that stem cells will exert their regenerative effect in the treatment of diabetes type 1 which is caused by damaged tissue. Prof. Dr. Jochen Seufert and Dr. Günter Päth from the University Hospital of Freiburg are investigating whether it is possible to use certain types of stem cells to regenerate the body’s own insulin production. The biological relationships involved have proved to be very complex. The two specialists are quick to point out that an early cure is not likely. However, they are cautiously optimistic about the far-reaching potential of stem cells.

Two separate defence systems? | 21.04.2009 | Science
Are the innate and the adaptive immune systems really completely independent from each other? Dr. Mathias Lucas from the University of Freiburg investigates receptor proteins that are found in the cells of both systems. It is possible that such systems might not only play a role in infections or cancer, but also in autoimmune diseases such as rheumatoid arthritis.

Anke Becker: looking closely at biological systems | 15.04.2009 | Science
Not that long ago, it took six months or more to sequence a single gene. Nowadays, modern genomics means that it takes less than a week to sequence an entire microorganism. This development means that scientists are more interested than ever in looking into biological systems as a whole. Professor Dr. Anke Becker from the University of Freiburg is investigating how groups of genes and molecules interact with each other. She is particularly interested in the signalling interactions between symbiotic bacteria and their host plants. Besides being a biologist, she has also knowledge of the fields of bioinformatics and robotics, indispensable for researchers investigating biological systems.

Sick hearts as instructors | 07.04.2009 | Science
Diseases are possibly one-way streets, at least this is what many scientists and physicians believe in the case of chronic cardiac insufficiency. Therefore, only the symptoms of this disease are treated. However, under certain conditions, some hearts manage to partially recover on their own. In a joint project with heart surgeons from Freiburg, pharmacologist Professor Dr. Lutz Hein and his team at the University of Freiburg, are working to uncover the mystery of spontaneous self-healing. Initial results suggest the involvement of genetic mechanisms, amongst other things.

All-rounders that export cancer | 07.04.2009 | Science
They are said to be rather like knights on white chargers. Medical researchers envisage a major potential in the regeneration of tissue. But these knights also have a dark side, some of them are delinquent and get itchy feet. We are referring to the migrating stem cells that have been the focus of attention for some years now, opening up potential new strategies for cancer research and therapy. Professor Dr. Thomas Brabletz and his team at the University Medical Centre in Freiburg are working on these stem cells that have an ability to generate new tumours anywhere in the body.

New ways to diagnose diseases | 07.04.2009 | Science
The Laboratory for Microoptics at the Institute of Microsystems Technology (IMTEK) at the University of Freiburg has developed an innovative endoscopic probe. The probe enables the examination of tissue inside the human body without causing damage and with a previously unequalled resolution (fraction of the human hair). An integrated tiltable mirror at the tip of the endoscope provides the user with an all-round view. A tunable microlens enables the user to focus on different tissue depths. The new method enables three-dimensional images to be recorded and may in future considerably increase the range of available diagnostic methods.

BERG medizinische Systeme: The Sonozentrum Freiburg – more than just baby cinema | 31.03.2009 | Industry
Wilfried Berg in the Freiburg Sonozentrum, standing in front of one of the ultrasound devices.
Many pregnant women are impatient to see their baby and are thrilled by an ultrasound image of the unborn child. But sonography has more to offer than just an image. The rapid development in the computer sector enables detailed images of almost all body tissues. The Freiburg-based company Berg medizinische Systeme e.K. offers ultrasound devices in the 'Sonozentrum Freiburg' (Sonography Centre), which have a surprising number of different functions. Managing Director Manfred Berg and his team have a clear, and passionate, focus on their clients.

Federal Cross of Merit for professional achievements and major human commitment | 30.03.2009 | News and Views
Nephrologist and endocrinologist Professor Dr. Hartmut Neumann was today awarded the German Federal Cross of Merit with Ribbon for his commitment to the research and treatment of the rare genetic “von Hippel-Lindau” disease. Neumann received the Medal from the Baden-Württemberg Minister of Science, Research and the Arts, Prof. Dr. Peter Frankenberg in a ceremony held at the University Medical Centre Freiburg.

Proteases – more than just the cutters of peptide bonds | 30.03.2009 | Science
The active centre of a protease (green) recognises the target sequence of a protein. The active centres of a protein are often not very specific.
Proteins are ubiquitous – they mediate almost all cellular processes, from signalling pathways to the transport of molecules and cell division. With funding provided by the DFG’s Emmy Noether programme, Dr. Oliver Schilling and his junior research group at the University of Freiburg, are developing tools that enable scientists to investigate the proteins of organisms in their functional context. Proteomics methods are helping Schilling’s team to understand a previously underestimated group of proteins – the proteases.

Bacteria can determine the flavour of wine | 30.03.2009 | Science
What is the connection between biotechnology and wine production? The answer is that there are more than 150 yeasts currently on the market that are used to influence the fermentation and hence the quality of wine. Enzyme preparations optimise the different steps in wine production. Dr. Jürgen Sigler from the State Institute of Viticulture and Oenology (WBI) is working on the development of biological methods to improve the flavour and taste of wine. Over the last few years, Sigler and his team have also looked at lactic acid bacteria and the effect they have on biological acid degradation.



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