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31.08.2010

Freiburg BioRegion – a Dynamic Region in the BioValley

Freiburg BioRegion, an attractive and dynamic region offering a high quality of life, is located in Germany but is close to both France and Switzerland. It is a partner of the three-nation BioValley network which combines the biotechnological potential of the centres in Freiburg (D), Basle (CH) and Strasbourg (F).


Mystery of nickel allergies solved

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Researchers from the University of Gießen and the Mannheim Medical Faculty along with colleagues from Freiburg, Münster and Munich, have made a fundamental contribution to deciphering the biological mechanisms behind nickel allergies. The results, which might be of great importance for developing innovative preventive and therapeutic approaches, have now been published in the current edition of “Nature Immunology”.
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Robert Murphy – intelligent computers and insights into cells

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Will humans, who consist of billions of cells and hundreds of billions of molecules, ever understand their own complexity? Robert F. Murphy, External Senior Fellow at the Freiburg Institute for Applied Sciences (FRIAS), is a pioneer in what is known as computational biology. Progress in this discipline is of major importance for medical and pharmaceutical research as well as the agricultural industry.
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Robert Murphy – intelligent computers and insights into cells | 29.08.2010 | Science
The photo shows a man with glasses and a poster with FRIAS written on it in the background.<br />
Will humans, who consist of billions of cells and hundreds of billions of molecules, ever understand their own complexity? Robert F. Murphy, External Senior Fellow at the Freiburg Institute for Applied Sciences (FRIAS), is a pioneer in what is known as computational biology. This discipline uses mathematical and computational methods to investigate the complexity of biological systems. Progress in this discipline is of major importance for medical and pharmaceutical research as well as the agricultural industry.

Mystery of nickel allergies solved | 23.08.2010 | Science
Researchers from the University of Gießen and the Mannheim Medical Faculty along with colleagues from Freiburg, Münster and Munich, have made a fundamental contribution to deciphering the biological mechanisms behind nickel allergies. The results, which might be of great importance for developing innovative preventive and therapeutic approaches, have now been published in the current edition of “Nature Immunology”.

IBAM GbR - Enzymes, neurotransmitters and Greek mountain tea | 09.08.2010 | Industry
The photo shows a green building.
The Denzlingen-based company IBAM GbR offers solutions that enable faster and cost-effective drug discovery. IBAM GbR was spun off from the University of Freiburg and supports industrial customers in identifying biochemical targets of potential drugs or the modes of action of enzymes and second messengers in the central nervous system and other tissues. Over the last few years, the company’s managing director Dr. Rainer Knörle, and his partner Dr. Peter Schnierle, have in co-operation with their industrial partners specialised on medicinal plants. The partners use modern biochemical methods to analyse the pharmaceutical effect of traditional medicinal plant extracts such as St. John’s wort, passion fruit, or Greek mountain tea.

Human protein produced in a moss bioreactor | 08.08.2010 | Science
The research group led by Prof. Ralf Reski is a moss specialist and has now, for the first time, succeeded in producing a human protein in a moss bioreactor – the complement factor H. The lack of this protein leads to age-related macular degeneration in about 50 million people worldwide. The complement factor H has been assigned ‘orphan drug’ status by the respective EU authorities.

Light into the darkness of the human immune system | 07.08.2010 | Science
Scientists from the Department of Molecular Immunology at the Faculty of Biology and the Centre for Biological Signalling Studies (BIOSS) at the University of Freiburg have discovered a new mechanism that regulates the development of B-lymphocytes in the human bone marrow.

Manfred Kist – 25 years of fascination for a stomach bacterium | 01.08.2010 | Science
Helicobacter pylori is a genus of bacteria that inhabits the human stomach. The bacteria can cause duodenal and gastric ulcers and are also linked to the development of gastric cancer. Prof. Dr. Manfred Kist from the Freiburg University Medical Centre has spent around 25 years of his scientific career on investigating H. pylori, a bent, rod-shaped bacterium.

Metal cubes, protein landscapes and the global nitrogen cycle | 26.07.2010 | Science
The photo shows coloured spheres surrounded by a dense net of blue lines.<br />
Modern methods used for the production of nitrogen for use in plant fertilisers and other applications are very efficient. Prof. Dr. Oliver Einsle and his team at the University of Freiburg have found a way to investigate the reactive centres of bacterial enzymes. All nitrogen-converting enzymes contain metal ions, and it is these metal ions that mediate the underlying chemical reactions.

Bernstein Center Freiburg | 17.07.2010 | Science
The photo shows the building of the Bernstein Centre Freiburg
From now on, the Bernstein Center Freiburg will become the central facility for coordinating research in the areas of computational neuroscience and neurotechnology in Freiburg. It will combine experimental and theoretical neurosciences and their applications in computer science, microsystems technology, and clinical use into a multidisciplinary research hub.

New Centre for Interactive Materials and Bioinspired Technologies (FIT) | 11.07.2010 | News and Views
The photo shows the Institute of Applied Microsystems Engineering at the University of Freiburg (FMF-Fit)
It’s official: Today, the Science Council approved the University of Freiburg’s proposal for the Freiburg Centre for Interactive Materials and Bioinspired Technologies (FIT). The 23-million-euro project can now get underway. The planned interdisciplinary, interinstitutional and transnational centre will become an innovative research institution with a special focus on basic research into interactive materials and intelligent systems.

Complex issues relating to membranes | 11.07.2010 | Industry
The photo shows the face of a man.
Dr. Uwe Schulte of the Freiburg-based biotech company Logopharm GmbH is a specialist in the analysis of membrane proteins, membrane protein complexes and functional networks involving membrane proteins. In an interview with BIOPRO, Schulte expresses his views on the direction research should take.



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Archive 2009



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BioValley “Science meets Business Day 2009” | 16.12.2009 | News and Views
This year’s presentations at the “Science meets Business Day 2009” once again showed that the exchange between science and the industry in the BioValley works extraordinarily well. The “Science meets Business Day 2009” concluded this year’s BioValley Life Science Week, where researchers from five completely different disciplines and their industrial partners presented their views on what makes the economic location in the area bordered by Germany, France and Switzerland so successful. Around 220 visitors, including more than 100 schoolchildren from the Merian School, were guided through a fascinating evening by Dr. Ralf Kindervater from BIOPRO Baden-Württemberg GmbH.

Science meets Business Day 2009 | 16.12.2009 | News and Views
The second part of the “Science meets Business Day” held in the Freiburg Concert House also provided guests with animated and exciting insights into the cooperation between research and industry. What enables neuroscientists to constantly obtain deeper insights into the dynamic network that is the “brain”? How do engineers manage to repress the extremely strong forces they encounter when handling the smallest quantities of liquid?

Arming the immune system against cancer | 15.12.2009 | Science
The theory that immune cells are able to attack tumours has long been a theory with only a minority of supporters. However, this theory is currently experiencing a renaissance. In the future, it might even be possible to specifically alter T-lymphocytes in order to improve their ability to identify and destroy certain tumour types. Prof. Dr. Hanspeter Pircher and his team at the Freiburg University Medical Centre are focusing on the development of methods for passive cellular immunisation: Can their methods provide the immune system with external weapons to destroy tumours and if so, which methods are the most effective ones?

Jochen Staiger – Looking for the basic module in the brain | 15.12.2009 | Science
Billions of nerve cells, billions of connections – how does the brain manage to reproduce the world in the right order and react accordingly? It is assumed that the different areas of the complex organ contain ordered processing units that make such processes possible. The neuroanatomist Prof. Dr. Jochen Staiger from the University of Freiburg is investigating the so-called barrels in the somatosensory cortex of rodents, which represent a body map with which the “tactile environment” can be perceived. Prof. Staiger is looking for the basic circuit in this highly ordered and structured part of the brain which enables the connection between perception and behaviour.

Cells to analyse air | 30.11.2009 | Science
The photo shows a gray cupboard containing a number of devices that can be seen through a window. The cupboard is standing on grass.
Exhaust gases, smoke generated by industry and private household combustion processes – every day we inhale a mixture of a broad range of particulate matter, potentially resulting in respiratory tract or cardiovascular diseases. Dr. Silvia Diabaté and her team from the Karlsruhe Institute of Technology (KIT) are examining the molecular mechanisms triggered by flue ash and other nanoparticles in the cells of the lung tissue. The researchers have developed an apparatus that simulates lung processes more realistically than cell cultures can. The so-called exposition chamber may also be used in the future as a biosensor for environmental monitoring.

The problem children of protein biochemistry | 30.11.2009 | Science
The schematic shows different models of folded proteins.<br />
A large number of cellular proteins are located in or on a membrane. Dr. Dirk Schneider from the University of Freiburg believes that biochemists who investigate such proteins must be a little crazy, as the methods required to isolate the molecules from their exotic environment, i.e. from the lipid bilayer, are extremely difficult and complicated. Research has long focused on water-soluble proteins. Schneider and his team have now taken on the challenge of finding out how proteins fold and assemble into complexes.

"You cannot afford to fail twice in Germany" | 28.11.2009 | Industry
Two men sitting at a table.
Prof. Dr. Bodo Liedvogel and Dr. Heinz Haubruck founded the company DIARECT AG in Freiburg in 1998. They not only brought 20 years of experience in industry to the company, but also their entire savings. In the following interview, Dr. Heinz Haubruck tells Christoph Bächtle about the return investors expect from companies, how to win over potential clients and the risks associated with setting up one’s own business.

Three new collaborative research centres in Baden-Württemberg | 24.11.2009 | Science
The German Research Foundation (DFG) is set to establish 17 new collaborative research centres (SFBs) on 1st January 2010. Ten of the new SFBs will focus on life science research projects, and will initially be funded for a period of four years with a total of 78 million euros in funding. One of the SFBs will be established at the University of Freiburg. Six of the 17 new SFBs are SFB/Transregio projects involving researchers from several German research institutions, including two SFBs that are to be coordinated by the University of Heidelberg.

New scientific spokesperson of the German Society for Regenerative Medicine | 19.11.2009 | News and Views
At this year’s general meeting of the German Society for Regenerative Medicine (GRM), Prof. Dr. Guido Nikkhah, Medical Director of the Department of Stereotactic Neurosurgery at the Neurocentre of the Freiburg University Medical Centre, was unanimously elected new scientific spokesperson of the GRM.

iGEM team Freiburg: a standing order for gold medals | 17.11.2009 | News and Views
The photo shows the team from Freiburg at the prize award ceremony at the Massachusetts Institute of Technology (MIT)
The Bioware team from Freiburg, an important part of the bioss cluster of excellence, has once again achieved resounding success: one gold medal and two special prizes at the iGEM competition (international Genetically Engineered Machine), the largest event for up-and-coming scientists focusing on synthetic biology. It was the turn of the research group heads, junior professor Dr. Kristian Müller and Dr. Katja Arndt, to participate in the competition with two teams, making it into the final round and showing that their Bioware and Software teams are among the six best biotech hubs in the world.



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