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16.12.2009

Science meets Business Day 2009

The second part of the “Science meets Business Day” held in the Freiburg Concert House also provided guests with animated and exciting insights into the cooperation between research and industry. What enables neuroscientists to constantly obtain deeper insights into the dynamic network that is the “brain”? How do engineers manage to repress the extremely strong forces they encounter when handling the smallest quantities of liquid?

Prof. Dr. Ulrich Egert from the Department of Microsystems Engineering (IMTEK) at the University of Freiburg and Karl-Heinz Boven from Multi Channel Systems GmbH in Reutlingen talked about “Brains on Chips: Use of microsystems technology to produce microelectrode arrays for brain research”. Egert explained that the brain consists of an immense number of very tightly arranged cells that undergo constant reorganisation. “Of the one million substances that the pharmaceutical industry tests for their potential use as drugs to combat Alzheimer’s or epilepsy, on average only one of the substances can be turned into a drug,” said the researcher. “We would like to find ways that enable us to predict as early as possible the effect of a certain pharmaceutical substance. But how is this possible considering that the brain is so dynamic?”

Up to 64,000 electrodes on one chip

Scientists can use electrodes to determine how cells react to the application of certain substances. Egert’s team and the company Multi Channel Systems have been working together for many years on the miniaturisation of electrode chips that are able to present the processes in sections of the brain. Egert and his team use chips with about 60 microscopic sensors to determine the behaviour of individual cells or entire networks. “This work requires a huge amount of technical know-how,” said Egert. “And we would have been unable to do all these measurements without the close collaboration with the engineers from Reutlingen.” Boven presented the company’s success story: Multi Channel Systems was founded in 1996, and sold its first electrode array back in 1997. The company now has 31 employees and makes about two thirds of its revenues abroad.


“The close cooperation with the IMTEK scientists is very important for us,” said Boven. “They come up with elements related to practical application. We then ask how we can turn these elements into technological devices.” How big do the electrodes have to be? How can the acquisition of data be organised and processed? For example, the company worked in cooperation with the scientists when it needed to construct a flow-through heater to keep the samples at a constant temperature. In addition, the company is constantly working on the optimisation of the chips’ material and structure, enabling the more effective aeration of the tissue and the provision of medium. “Nowadays we are able to produce chips with 256 electrodes,” said Boven. “The IMTEK testing laboratory even has prototypes with a thousand electrodes.” The long-term goal of the cooperation partners is to produce chips with 64,000 electrodes.

Source of inspiration: industry

A contribution from:
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mn - 16.12.2009
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