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27.07.2010

Freiburg BioRegion – a Dynamic Region in the BioValley

Freiburg BioRegion, an attractive and dynamic region offering a high quality of life, is located in Germany but is close to both France and Switzerland. It is a partner of the three-nation BioValley network which combines the biotechnological potential of the centres in Freiburg (D), Basle (CH) and Strasbourg (F).


Bernstein Centre Freiburg

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From now on, the Bernstein Centre Freiburg with its offices at Hansastrasse 9A will become the central facility for coordinating research in the areas of computational neuroscience and neurotechnology in Freiburg. It will combine experimental and theoretical neurosciences and their applications in computer science, microsystems technology, and clinical use into a large, multidisciplinary research hub.
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Metal cubes, protein landscapes and the global nitrogen cycle

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Modern methods used for the production of nitrogen for use in plant fertilisers and other applications are very efficient. Prof. Dr. Oliver Einsle and his team at the University of Freiburg have found a way to investigate the reactive centres of bacterial enzymes. All nitrogen-converting enzymes contain metal ions, and it is these metal ions that mediate the underlying chemical reactions.
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Modern methods used for the production of nitrogen for use in plant fertilisers and other applications are very efficient. Prof. Dr. Oliver Einsle and his team at the University of Freiburg have found a way to investigate the reactive centres of bacterial enzymes. All nitrogen-converting enzymes contain metal ions, and it is these metal ions that mediate the underlying chemical reactions.

From now on, the Bernstein Center Freiburg will become the central facility for coordinating research in the areas of computational neuroscience and neurotechnology in Freiburg. It will combine experimental and theoretical neurosciences and their applications in computer science, microsystems technology, and clinical use into a multidisciplinary research hub.

It’s official: Today, the Science Council approved the University of Freiburg’s proposal for the Freiburg Centre for Interactive Materials and Bioinspired Technologies (FIT). The 23-million-euro project can now get underway. The planned interdisciplinary, interinstitutional and transnational centre will become an innovative research institution with a special focus on basic research into interactive materials and intelligent systems.

Dr. Uwe Schulte of the Freiburg-based biotech company Logopharm GmbH is a specialist in the analysis of membrane proteins, membrane protein complexes and functional networks involving membrane proteins. In an interview with BIOPRO, Schulte expresses his views on the direction research should take.

Scientists from the University of Freiburg and the University of Frankfurt have elucidated the architecture of the biggest protein complex of the cellular respiratory chain. They discovered in this molecular complex a previously unknown energy conversion mechanism, which is essential for the cell to be able to utilise the energy contained in food.

The powerhouses of cells are surprisingly dependent on external help. More than ninety per cent of all proteins required by the mitochondria are produced outside the outer mitochondrial membrane. How are these proteins transported across the membrane and how do they find their way into the mitochondria? A group of researchers led by Prof. Dr. Chris Meisinger at the University of Freiburg has been investigating the role of large protein complexes in the outer mitochondrial membrane for many years.

The potential of Microalgae cannot yet be optimally used on the large scale. The bioprocess engineer Dr. Rosa Rosello and her team at the Karlsruhe Institute of Technology (KIT) are investigating the conditions under which different microalgae species can optimally grow in photobioreactors and lead to high product yields. It is all a question of light and shade.

ATG:biosynthetics GmbH, based in Merzhausen close to Freiburg, produces biological systems that can combine gene constituents following a construction kit principle. The company provides the pharmaceutical industry and basic researchers with products that have specifically chosen properties.

The Freiburg Materials Research Centre (FMF), which is part of the University of Freiburg, recently celebrated its 20th anniversary in the Freiburg Concert Hall. As a central institution of the University of Freiburg, the FMF has been focusing on interdisciplinary basic research and contract research in the field of new materials and materials-related technologies since 1990.

At the SMBC 2010 in Freiburg, systems biologists are optimistic about the future: their goal is to develop new models for whole organs or even the whole body.




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Archive 2009



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This year’s presentations at the “Science meets Business Day 2009” once again showed that the exchange between science and the industry in the BioValley works extraordinarily well. The “Science meets Business Day 2009” concluded this year’s BioValley Life Science Week, where researchers from five completely different disciplines and their industrial partners presented their views on what makes the economic location in the area bordered by Germany, France and Switzerland so successful. Around 220 visitors, including more than 100 schoolchildren from the Merian School, were guided through a fascinating evening by Dr. Ralf Kindervater from BIOPRO Baden-Württemberg GmbH.

The second part of the “Science meets Business Day” held in the Freiburg Concert House also provided guests with animated and exciting insights into the cooperation between research and industry. What enables neuroscientists to constantly obtain deeper insights into the dynamic network that is the “brain”? How do engineers manage to repress the extremely strong forces they encounter when handling the smallest quantities of liquid?

The theory that immune cells are able to attack tumours has long been a theory with only a minority of supporters. However, this theory is currently experiencing a renaissance. In the future, it might even be possible to specifically alter T-lymphocytes in order to improve their ability to identify and destroy certain tumour types. Prof. Dr. Hanspeter Pircher and his team at the Freiburg University Medical Centre are focusing on the development of methods for passive cellular immunisation: Can their methods provide the immune system with external weapons to destroy tumours and if so, which methods are the most effective ones?

Billions of nerve cells, billions of connections – how does the brain manage to reproduce the world in the right order and react accordingly? It is assumed that the different areas of the complex organ contain ordered processing units that make such processes possible. The neuroanatomist Prof. Dr. Jochen Staiger from the University of Freiburg is investigating the so-called barrels in the somatosensory cortex of rodents, which represent a body map with which the “tactile environment” can be perceived. Prof. Staiger is looking for the basic circuit in this highly ordered and structured part of the brain which enables the connection between perception and behaviour.

Cells to analyse air | 30.11.2009 | Science
Exhaust gases, smoke generated by industry and private household combustion processes – every day we inhale a mixture of a broad range of particulate matter, potentially resulting in respiratory tract or cardiovascular diseases. Dr. Silvia Diabaté and her team from the Karlsruhe Institute of Technology (KIT) are examining the molecular mechanisms triggered by flue ash and other nanoparticles in the cells of the lung tissue. The researchers have developed an apparatus that simulates lung processes more realistically than cell cultures can. The so-called exposition chamber may also be used in the future as a biosensor for environmental monitoring.

A large number of cellular proteins are located in or on a membrane. Dr. Dirk Schneider from the University of Freiburg believes that biochemists who investigate such proteins must be a little crazy, as the methods required to isolate the molecules from their exotic environment, i.e. from the lipid bilayer, are extremely difficult and complicated. Research has long focused on water-soluble proteins. Schneider and his team have now taken on the challenge of finding out how proteins fold and assemble into complexes.

Prof. Dr. Bodo Liedvogel and Dr. Heinz Haubruck founded the company DIARECT AG in Freiburg in 1998. They not only brought 20 years of experience in industry to the company, but also their entire savings. In the following interview, Dr. Heinz Haubruck tells Christoph Bächtle about the return investors expect from companies, how to win over potential clients and the risks associated with setting up one’s own business.

The German Research Foundation (DFG) is set to establish 17 new collaborative research centres (SFBs) on 1st January 2010. Ten of the new SFBs will focus on life science research projects, and will initially be funded for a period of four years with a total of 78 million euros in funding. One of the SFBs will be established at the University of Freiburg. Six of the 17 new SFBs are SFB/Transregio projects involving researchers from several German research institutions, including two SFBs that are to be coordinated by the University of Heidelberg.

At this year’s general meeting of the German Society for Regenerative Medicine (GRM), Prof. Dr. Guido Nikkhah, Medical Director of the Department of Stereotactic Neurosurgery at the Neurocentre of the Freiburg University Medical Centre, was unanimously elected new scientific spokesperson of the GRM.

The Bioware team from Freiburg, an important part of the bioss cluster of excellence, has once again achieved resounding success: one gold medal and two special prizes at the iGEM competition (international Genetically Engineered Machine), the largest event for up-and-coming scientists focusing on synthetic biology. It was the turn of the research group heads, junior professor Dr. Kristian Müller and Dr. Katja Arndt, to participate in the competition with two teams, making it into the final round and showing that their Bioware and Software teams are among the six best biotech hubs in the world.



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